与COVID-19流行病相关的产前困扰和婴儿功能性大脑发育
Aliza Jaffer1, Kathryn Y Manning1, Gerald F Giesbrecht1
1University of Calgary, Calgary, Alberta, Canada.
JAACAP open
|September 9, 2025
概括
孕产妇产前痛苦,包括焦虑和抑郁,与婴儿听觉大脑网络的功能连接增强有关. 这种痛苦也与婴儿个人社会发展得分较高相关,这表明潜在的早期发育影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 孕产妇健康 孕产妇健康
背景情况:
- 产前心理困扰 (焦虑,抑郁) 可能会对胎儿大脑发育和婴儿行为产生负面影响.
- 随着COVID-19大流行,产前困难增加,引发了对婴儿神经发育结果的担忧.
研究的目的:
- 为了研究产前母亲的痛苦和婴儿大脑功能连接之间的关系.
- 为了检查产前母亲的痛苦和婴儿的行为之间的联系.
- 探索婴儿大脑连接和行为之间的潜在联系,在孕产妇产前困境的背景下.
主要方法:
- 在COVID-19流行病研究期间,从怀孕期调查了63对母婴对.
- 母亲在怀孕期间报告了抑郁和焦虑症状,创建了一个产前孕产妇痛苦指标.
- 婴儿大脑休息状态功能性MRI (rs-fMRI) 在3个月时获得;婴儿行为在6个月和12个月时使用IBQ-R和ASQ-3.
主要成果:
- 更高的产前母亲痛苦与婴儿听觉网络中更强的功能连接相关 (p=0.01).
- 产前母亲的痛苦与较高的婴儿ASQ-3个人社会分数 (p=0.006) 有关.
- 在婴儿大脑连接和婴儿行为之间没有发现任何显著的关联.
结论:
- 早期发育的大脑网络,如听觉网络,可能会显示母亲产前痛苦的影响.
- 产前痛苦和婴儿行为评分之间的关联可能表明需要进一步调查的补偿机制.
- 产前应急暴露的长期行为表现需要进一步的研究.
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