阿西克洛维尔诱导的毒性:一个案例报告
Karim Chami1, Khalid K Khaleq2,3, Manal El Goubi3
1Anesthesia and Critical Care, Hôpital Universitaire International Cheikh Khalifa Ibn Zaid/Faculty of Pharmacy, Mohammed VI University of Health Sciences, Casablanca, MAR.
Cureus
|September 9, 2025
概括
抗病毒药物阿西克洛维尔可以导致损伤 (毒性),包括急性损伤. 及时停止阿西克洛维尔和监测功能对于患者的康复和预防严重后果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 阿西克洛维尔是一种重要的抗病毒药物.
- 毒性是已知的阿西克洛维尔的不良影响,表现为急性损伤 (AKI),管间炎和水晶诱导的病.
- 阿西克洛维尔诱导脏毒性的危险因素包括高剂量和脱水.
研究的目的:
- 报告一名年轻患者因静脉注射阿西克洛维尔而出现急性功能衰竭的病例.
- 强调在阿西克洛维尔治疗期间警性功能监测的重要性.
- 为了突出阿西克洛维尔诱导的毒性在药物停用后的快速可逆性.
主要方法:
- 一个20岁的女性患者的案例研究,怀疑患有疹性脑膜炎.
- 静脉注射阿西克洛维尔以标准脑膜剂量 (15 mg/kg每8小时).
- 在停止服用阿西克洛维尔后,对功能和临床反应的监测.
主要成果:
- 患者在开始静脉注射阿西克洛维尔后48小时内出现急性功能衰竭.
- 停用阿西克洛维尔导致功能在24小时内显著改善.
- 这一案例表明,阿西克洛维尔和急性损伤之间存在明显的联系.
结论:
- 在敏感个体中,即使是标准剂量,阿西克洛维尔也会导致急性损伤.
- 对于接受阿西克洛维尔的患者来说,密切监测功能,特别是在治疗的前48小时内,这是必不可少的.
- 早期检测和干预,包括戒药,可以迅速逆转阿西克洛维尔诱导的毒性.
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