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在心力衰竭中探索血小板与淋巴细胞比率的风险分层:系统性审查

Mohamed Babikir Elbashir Hamid¹, Moayad H Ali², Abdalla Bashier Abdalla Elbashier³

¹Cardiology, Prince Mohammad Bin Abdulaziz Hospital, Al-Madinah, SAU.

|September 9, 2025

概括

血小板与淋巴细胞的比率 (PLR) 显示了急性心力衰竭 (HF) 和ICU设置中的死亡率的预后价值,特别是在其他炎症标志物的情况下. 它在稳定的HF中的实用性不太清楚,需要进一步的研究和标准化.

科学领域:

心脏病学心脏病学
炎症生物标志物炎症生物标志物
系统审查是系统的审查.

背景情况:

心力衰竭 (HF) 构成了全球严重的健康负担,需要有效的预后生物标志物.
血小板与淋巴细胞的比率 (PLR) 是一个新兴的炎症标志物,具有潜在的心血管预后价值.
目前关于PLR在HF预后中的有用性的证据是不一致的.

研究的目的:

系统地审查和综合关于PLR在心力衰竭中的预后价值的证据.
评估PLR与HF患者的死亡率和住院治疗的关联.
评估PLR在HF多标志物预后模型中的作用.

主要方法:

在PubMed,Scopus,Web of Science和Cochrane图书馆的系统文献搜索 (2020年1月至2025年6月).
纳入了14项针对成年HF患者的观察性研究,不包括评论和非英语文章.
由于异质性的叙述合成;使用纽卡斯尔-太华尺度评估偏差风险.

主要成果:

升高的PLR与重症监护室 (ICU) 和急性HF环境中的死亡率增加有很强的相关性.
结合PLR和中性粒细胞与淋巴细胞比率 (NLR) 在多标志物模型中证明了附加的预后价值.
在稳定或社区居住的HF队列中,PLR显示出有限的预测能力;高异质性影响了元分析.

结论:

PLR在急性HF中提供增量预后价值,特别是当与其他炎症标志物如NLR集成时.
在慢性HF中PLR的独立预后效用仍然不确定.
标准化PLR测量和前性研究对于澄清其在HF中的临床作用至关重要.

关键词:

心脏衰竭是因为心脏衰竭.这是一种炎症炎症炎症炎症.血小板与淋巴细胞的比率.预后预后预后风险分层的分层化系统性审查系统性审查

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