跨代皮肤适应妊娠晚期的热应激在曾孙女的皮肤适应
B D Davidson1, K Hardy1, J Laporta1
1Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706.
JDS communications
|September 9, 2025
概括
孕期母亲的热应激会通过改变脂质腺体的大小和数量,影响曾孙女的皮肤. 这表明畜牧业热适应能力的跨代编程.
科学领域:
- 动物科学动物科学
- 生殖生物学 生殖生物学
- 皮肤病学 皮肤病学
背景情况:
- 恒温和温度调节是受到皮肤和头发影响的关键生理过程.
- 已被证明,孕期晚期母亲的热应激会诱导后代和后代的头发和皮肤的适应.
研究的目的:
- 调查孕期晚期母亲热应激对曾孙女 (F3代) 头发和皮肤特征的跨代影响.
主要方法:
- 孕妇 (F0) 在妊娠晚期暴露于热应激或冷却.
- 这些母的后代 (F1,F2) 出生,F2的母牛携带生殖线暴露.
- 从70天的F3公牛 (曾孙女) 采集了头发和皮肤活检,以分析头发,表皮,皮肤,汗腺 (SWTG) 和脂质腺 (SEBG).
主要成果:
- 在头发长度/直径,表皮厚度/面积,SWTG深度,SEBG深度或皮肤厚度方面没有发现显著差异.
- 与冷却对照组 (CL_F3) 相比,热应激后的曾孙女 (HT_F3) 表现出较少和较小的脂质腺体.
- 一个趋势表明HT_F3公牛的皮肤表面到最深的汗腺的距离较短.
结论:
- 孕期晚期的热应激会导致血脂腺特征和汗腺局部的跨代变化.
- 这些发现表明,由于早期的环境暴露,在几代人之间可能会对出生后的热适应性进行编程.
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