人参补充剂对心血管疾病风险因素的影响:综合系统性审查和剂量反应元分析
Ali Jafari1,2, Helia Mardani3, Maryam Abbastabar4
1Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, https://ror.org/034m2b326National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The British journal of nutrition
|September 9, 2025
概括
人参补充剂有望改善心血管疾病 (CVD) 风险因素,特别是炎症标志物和氧化应激. 虽然不影响所有指标,但它对关键的生化指标产生积极影响,这表明潜在的健康益处.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 临床研究表明,人参可能有益于心血管疾病 (CVD) 风险因素,但结果尚不确定.
- 为了巩固现有证据,进行了系统审查和元分析.
研究的目的:
- 评估人参补充剂对各种心血管疾病相关风险因素的影响.
- 分析剂量反应关系和补充剂持续时间的影响.
主要方法:
- 70项涉及4506名参与者的研究的系统审查和元分析.
- 电子数据库搜索 (Embase,科学网,Scopus,PubMed,CENTRAL) 截至 2024 年 8 月.
- 统计分析包括随机效应模型,元回归和非线性建模.
主要成果:
- 人参补充剂显著影响了高灵敏度C-反应蛋白,玛-谷氨基转移酶,谷氨还原酶,活性氧物种和超氧化物转移酶.
- 转基因回归显示,人参剂量与胰岛素耐药性,持续时间与马隆迪化物之间存在关联.
- 剂量反应分析显示,人参剂量与禁食血糖,炎症标志物和腹筋血压之间存在显著联系.
结论:
- 人参补充剂与炎症标志物,肝功能和氧化应激参数的改善有关.
- 没有观察到对人类指数,血压,血糖特征,脂质特征,阿迪波金或心率的显著影响.
- 进一步的研究可能会澄清针对特定心血管疾病风险因素管理的最佳人参剂量和持续时间.
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