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针对非肌肉侵入性膀癌的瘤病毒治疗:目前的状况和未来的方向
Hiroshi Kitamura1, Naotaka Nishiyama
1Department of Urology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Current opinion in urology
|September 9, 2025
概括
瘤溶解性病毒疗法为对BCG治疗无反应的非肌肉侵入性膀癌 (NMIBC) 提供了一个有前途的膀保护替代方案. 第三阶段试验显示了高的完全响应率,可能成为新的护理标准.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫治疗是一种免疫疗法.
背景情况:
- 患有BCG不响应疾病的非肌肉侵入性膀癌 (NMIBC) 患者面临有限的治疗选择.
- 激进的囊切除术往往是唯一的替代方案,强调了需要膀保护策略的需要.
- 目前正在进行的Bacillus Calmette-Guérin (BCG) 短缺加剧了对新疗法的需求.
研究的目的:
- 对BCG不响应的NMIBC进行型病毒治疗的新兴作用进行审查.
- 检查这种患者群体的新型肠道治疗方法.
- 评估瘤病毒作为保护膀的替代品的潜力.
主要方法:
- 对临床试验的审查,涉及NMIBC的型病毒平台.
- 从第三阶段试验的疗效和安全性数据的分析,包括cretostimogene grenadenorepvec.
- 检查组合治疗结果和其他病毒平台 (简单疹,科克萨基,麻疹病毒).
主要成果:
- 多种瘤性病毒平台在NMIBC临床试验中显示出有希望的疗效和安全性.
- 在BCG不响应的 carcinoma in situ中,Cretostimogene grenadenorepvec实现了74.5%的完全响应率.
- 与布罗利祖马布的联合治疗在12个月内显示出57.1%的完全响应率,防止肌肉侵入性疾病的进展.
结论:
- 瘤性病毒疗法代表了BCG不响应的NMIBC中膀保护治疗的范式转变.
- 第三阶段数据支持监管批准,将这些疗法定位为潜在的新护理标准.
- 这些新的治疗方法为改善结果和避免激进手术提供了希望.
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