诊断性表现的前激素时间和激活的部分血栓状质素时间在儿童:一个服务评估
Gerard Gurumurthy1, Mikias Lemma1, Lianna Reynolds2
1The University of Manchester, Manchester, UK.
International journal of laboratory hematology
|September 9, 2025
概括
使用前血时间 (PT) 和激活的局部血栓形成时间 (aPTT) 的儿科凝血查显示高异常结果率,许多需要临床关注. 改进测试利用对于有效诊断出血障碍至关重要.
科学领域:
- 儿科血液学 儿科血液学
- 临床病理学 临床病理学
- 诊断测试 诊断测试 诊断测试
背景情况:
- 凝血查,包括前血时间 (PT) 和激活的部分血栓形成时间 (aPTT),是儿科标准用于识别出血障碍和指导管理.
- 对PT和aPTT测试在三级儿科中心的当前利用率和诊断收益率进行了评估.
研究的目的:
- 评估在儿科环境中使用凝血查测试 (PT和aPTT) 的趋势.
- 为了确定异常PT和aPTT结果的诊断产量和临床意义.
- 确定在儿科实践中改进这些测试的使用领域.
主要方法:
- 对2024年四个月期间收到的所有PT和aPTT样本的分析.
- 记录的总请求,样本拒绝率,异常结果的模式 (孤立的PT,孤立的aPTT,组合) 和临床相关性.
- 利用尤登指数来确定与遗传性出血障碍相关的切断值.
主要成果:
- 总共分析了2808个凝血概况,排斥率为15.7%.
- 在有效的测试中,17.0%的患者显示异常结果,其中28.8%的被选中的患者显示异常结果导致新的诊断.
- 孤立的aPTT> 31.4s与遗传性疾病相关 (AUC> 0.8),与孤立的PT不同.
结论:
- 有相当数量的凝血查样本被拒绝,一些异常结果没有被跟进.
- 大多数异常发现,特别是aPTT> 33.1s,具有临床意义,影响诊断和管理.
- 显然需要在儿科临床实践中优化PT和aPTT测试的使用.
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