从基础到应用:磁纳米粒子用于MRI成像和NIR诱导的热激活在组织模拟环境中
Radu Lapusan1, Andreea Balmus1,2, Radu Fechete3,4
1Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, 1 M. Kogalniceanu Street, 400084, Cluj-Napoca, Romania. radu.lapusan@ubbcluj.ro.
Journal of materials chemistry. B
|September 9, 2025
概括
超微小的氧化铁纳米颗粒显示出作为MRI对比和近红外 (NIR) 光热疗法的双重用途剂的前景. 在970nm优化后,它们为潜在的癌症治疗提供深层组织透.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 医疗成像医学成像
背景情况:
- 磁纳米颗粒被研究为MRI对比度和高热量.
- 它们在模仿组织环境中的光热效率尚不清楚.
研究的目的:
- 评估用于综合成像和光热疗法的超小氧化铁纳米颗粒.
- 在临床相关条件下,评估现实的,类似组织的幻影的性能.
主要方法:
- 使用了3D花粉幽灵,其光学和热性质与组织相似.
- 在850,970和1100nm NIR光下测试光热转换.
- 评估了MRI对比度增强,并与Gadovist使用放松计和MRI在1.5T和11.7T时进行比较.
主要成果:
- 最佳光热效率 (71.59%) 在970nm达到,透深度为2.1cm.
- 在不同度下显示出显著的T1-T2MRI对比度增强.
- 在临床前和临床MRI系统中验证的性能.
结论:
- 超微小的氧化铁纳米颗粒显示MRI引导光热疗法的双模式治疗学潜力.
- 幻影模型为翻译评估提供了一个高保真性平台.
- 结果支持进一步的体内研究,用于癌症治疗应用.
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