相关实验视频
Updated: Jan 18, 2026

07:15
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
61.5K
过敏性鼻炎中高性盐水鼻灌的有效性:系统性审查和元分析
Nishtha Singh1, Sheetu Singh2, Arvind Kumar Sharma3
1Department of Respiratory Medicine, Asthma Bhawan, Jaipur, India; drnishthasingh@gmail.com.
Allergologia et immunopathologia
|September 9, 2025
概括
高压盐水鼻灌 (HSNI) 有效地减少过敏性鼻炎症状和药物使用,无论是成人还是儿童. 这一元分析证实了HSNI的证实.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏学 过敏学
- 基于证据的医学是基于证据的医学.
背景情况:
- 盐水鼻水是对过敏性鼻炎 (AR) 的常见治疗方法.
- 对AR症状缓解的最佳盐水度进行了辩论.
- 3%的高盐水鼻灌 (HSNI) 与0.9%的同盐水的比较疗效需要进一步评估.
研究的目的:
- 评估3%的HSNI与对照剂 (同位素盐水或无盐水) 相比在降低AR患者鼻腔症状得分方面的有效性.
- 评估HSNI对AR抗胰岛素使用的影响.
- 通过元分析综合随机对照试验 (RCT) 的证据.
主要方法:
- 在PubMed,Scopus和Cochrane Central的系统文献搜索RCT,将3%的HSNI与对照进行比较.
- 包括到2024年5月8日发表的研究.
- 使用随机效应模型对总鼻腔症状得分和抗组胺剂使用的元分析.
主要成果:
- 纳入了9个RCT,包括645名患者.
- 与对照组相比,HSNI显著降低了成年人 (MD = -2.09) 和儿童 (MD = -0.97) 的鼻腔症状得分.
- 与HSNI (OR = 0.39) 相比,抗胰岛素的使用明显较低,但与单独的同位素盐水相比没有发现显著差异 (OR = 0.69).
结论:
- 3%的HSNI有效地减少了过敏性鼻炎患者的鼻腔症状和药物需求.
- 在不同年龄组中,HSNI显示出有效性.
- 进一步的研究可能会澄清单独高压和同位素盐水之间的直接比较.
相关概念视频
Suctioning the Nasopharyngeal Airway
3.1K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
3.1K
Upper Respiratory Drugs: Decongestants
839
Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in...
Most decongestants are readily available over-the-counter in...
839
Drugs Used in Upper Respiratory Disorders: Overview
632
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
632
Open Angle Glaucoma: Treatment
963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
Adrenergic Agonists: Mixed-Action Agents
1.4K
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
1.4K
Epistaxis
519
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
519

