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针对精神分裂症负面症状的重用抗高血压药物:系统性审查和元分析
Thiago Carnaval1,2,3,4, My Bui1,2,5, Jesús Villoria4
1Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain.
Psychiatry and clinical neurosciences
|September 9, 2025
概括
重用抗高血压药物 (AHTs) 显著改善了精神分裂症患者的负面,积极和总体症状. 这一系统性审查发现AHT是一种安全有效的精神分裂症辅助治疗,特别是酸.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 精神分裂症表现出复杂的症状,目前抗精神病药对负面症状和治疗耐药性的有效性有限.
- 负面症状是持久的,并显著影响精神分裂症患者的功能障碍.
- 对于改善精神分裂症治疗结果的新型辅助疗法有着至关重要的需求.
研究的目的:
- 系统地审查和元分析重用抗高血压药物 (AHT) 作为精神分裂症辅助治疗的疗效和安全性.
- 评估AHT对精神分裂症的积极,消极和一般精神病理症状的影响.
- 评估与精神分裂症治疗中的辅助AHT相关的安全性和不良事件率.
主要方法:
- 自2000年以来发表的双盲随机对照试验 (RCT) 的系统综述和元分析.
- 搜索了包括PubMed,Web of Science和Scopus在内的数据库,寻找相关研究.
- 包括12个RCT和436名参与者,分析了对酸,利尿剂,telmisartan和克隆尼丁的数据.
主要成果:
- 抗高血压药物显著改善了负面症状 (SMD = -0.37),积极症状 (SMD = -0.29),一般精神病理 (SMD = -0.28) 和总症状 (SMD = -0.44).
- 酸尼特罗普鲁塞德显示出特别的疗效,一些利尿剂显示出初步的益处.
- 在包括的研究中没有观察到不良事件的显著增加.
结论:
- 重用抗高血压药物,特别是酸,显示出作为精神分裂症辅助治疗的希望,改善各种症状领域.
- 这些发现表明,AHT可以安全地整合到精神分裂症治疗方案中.
- 更大的,长期的RCT是必要的,以确认这些初步发现,并建立最终的临床建议.
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