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TCRdb 2.0:一个更新的T细胞受体序列数据库

Tao Yue^1,2, Si-Yi Chen³, Wen-Kang Shen^1,4

¹Department of Thoracic Surgery, West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Nucleic acids research

|September 9, 2025

概括

TCRdb2.0是一个大大扩展的T细胞受体 (TCR) 数据库,现在包含来自不同样本的7亿个序列. 该资源通过全面的TCR数据增强了免疫反应研究.

科学领域:

免疫学免疫学免疫学
生物信息学是一种生物信息学.
基因组学就是基因组学.

背景情况:

T细胞受体 (TCR) 谱系测序对于理解免疫反应至关重要.
现有的TCR数据库缺乏来自不同样本的全面数据.
需要一个扩展和增强的TCR序列资源.

研究的目的:

为了介绍TCRdb2.0,一个更新和显著扩展的T细胞受体序列数据库.
为分析TCR目录数据提供一个全面的资源.
加强对TCR在健康和疾病中的功能研究.

主要方法:

从19701个TCR-Seq样本中纳入大约7亿个TCR序列.
包括来自Gamma delta (γδ) T细胞的TCR序列.
整合与治疗相关的TCR-Seq数据集,包括PD-1阻断免疫治疗数据.
从健康个体构建了一个广泛的TCR序列参考集.
重新设计搜索和下载功能,以实现灵活的数据检索.

主要成果:

TCRdb2.0是迄今为止最全面的TCR序列数据库,数据量大幅增加.
该数据库现在包括马三角 (γδ) T细胞TCR序列.
整合了与治疗相关的数据集和来自健康样本的大量参考数据集.
可提供增强的浏览,搜索和下载功能.

结论:

TCRdb2.0为T细胞受体研究提供了一个宝贵的,扩展的资源.
该数据库支持对TCRs在各种健康和疾病条件中的详细功能研究.
它的全面数据和用户友好的界面有助于免疫学和相关领域的进步.

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