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相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K

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相关实验视频

Updated: Jan 18, 2026

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

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TCRdb 2.0:一个更新的T细胞受体序列数据库.

Tao Yue1,2, Si-Yi Chen3, Wen-Kang Shen1,4

  • 1Department of Thoracic Surgery, West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Nucleic acids research
|September 9, 2025
PubMed
概括

TCRdb2.0是一个大大扩展的T细胞受体 (TCR) 数据库,现在包含来自不同样本的7亿个序列. 该资源通过全面的TCR数据增强了免疫反应研究.

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

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相关实验视频

Last Updated: Jan 18, 2026

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • T细胞受体 (TCR) 谱系测序对于理解免疫反应至关重要.
  • 现有的TCR数据库缺乏来自不同样本的全面数据.
  • 需要一个扩展和增强的TCR序列资源.

研究的目的:

  • 为了介绍TCRdb2.0,一个更新和显著扩展的T细胞受体序列数据库.
  • 为分析TCR目录数据提供一个全面的资源.
  • 加强对TCR在健康和疾病中的功能研究.

主要方法:

  • 从19701个TCR-Seq样本中纳入大约7亿个TCR序列.
  • 包括来自Gamma delta (γδ) T细胞的TCR序列.
  • 整合与治疗相关的TCR-Seq数据集,包括PD-1阻断免疫治疗数据.
  • 从健康个体构建了一个广泛的TCR序列参考集.
  • 重新设计搜索和下载功能,以实现灵活的数据检索.

主要成果:

  • TCRdb2.0是迄今为止最全面的TCR序列数据库,数据量大幅增加.
  • 该数据库现在包括马三角 (γδ) T细胞TCR序列.
  • 整合了与治疗相关的数据集和来自健康样本的大量参考数据集.
  • 可提供增强的浏览,搜索和下载功能.

结论:

  • TCRdb2.0为T细胞受体研究提供了一个宝贵的,扩展的资源.
  • 该数据库支持对TCRs在各种健康和疾病条件中的详细功能研究.
  • 它的全面数据和用户友好的界面有助于免疫学和相关领域的进步.