儿童群体的角质交叉链接:系统性审查和未来的前景
Claudia R Morgado1, Nicole B Larivoir1, Juliana F Santos1
1From the Department of Ophthalmology at University of São Paulo, São Paulo, Brazil.
Journal of refractive surgery (Thorofare, N.J. : 1995)
|September 9, 2025
概括
角膜交叉连接 (CXL) 在18岁以下的患者中有效稳定角. 标准和加速的CXL协议都显示出高的成功率,为儿科角提供了安全的治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 儿科眼科护理 儿科眼科护理
背景情况:
- 角膜是一种渐进的角膜脱落,影响年轻人.
- 有效的治疗对于预防儿科患者视力丧失至关重要.
- 角膜交叉链接 (CXL) 旨在阻止角膜的进展.
研究的目的:
- 评估标准和加速角膜交叉连接 (CXL) 协议的有效性.
- 分析诊断为角质的18岁以下患者的稳定结果.
- 在儿科人口中比较不同的CXL方法.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 在PubMed和Scopus数据库中进行全面的文献搜索 (2024年12月).
- 从35个符合条件的研究中分析了最大的角膜测量测量 (手术前和手术后).
主要成果:
- 包括35项研究中的2186只眼睛 (15个标准CXL,11个加速CXL,9个比较).
- 在各种CXL协议中观察到超过80%的稳定率.
- 年龄较小,角质的严重程度和形异常度影响了治疗的有效性.
结论:
- 标准和加速CXL对于儿科角是安全有效的.
- 在儿童中,CXL提供了一种可行的治疗选择,以稳定角膜脱膜症.
- 进一步的研究可能会根据影响因素完善患者的选择.
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