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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Immune Response Against Viral Pathogens01:29

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
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相关实验视频

Updated: Jan 18, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
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CD4 T 细胞在经典的 T 细胞激活后获得天生的能力.

Nima Yassini1, Eva Goljat1, Camilla Panetti1

  • 1Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

European journal of immunology
|September 9, 2025
PubMed
概括

免疫力至关重要的先天性T (TIA) 细胞可以从天真的CD4 T细胞产生. 这些TIA细胞独立于TCR信号产生IFN-γ,帮助对感染的反应.

关键词:
帮助性T细胞是帮助性T细胞.宿主/病原体相互作用这是先天免疫力.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞免疫学 细胞免疫学
  • 传染性疾病 传染性疾病

背景情况:

  • 记忆T细胞增强了二次病原体的反应.
  • 经过病毒的先天性T (TIA) 细胞产生IFN-γ独立于T细胞受体 (TCR) 信号.
  • TIA细胞的发育途径尚不清楚.

研究的目的:

  • 研究CD4 TIA细胞的起源和特征.
  • 为了确定纯粹的CD4 T细胞是否可以被诱导成为TIA细胞.
  • 评估实验诱导的TIA细胞的体内功能.

主要方法:

  • 在试验室使用TCR和CD28共同刺激对原始小鼠和人类CD4T细胞诱导TIA细胞功能.
  • 评估细胞因子介导的,独立于TCR的IFN-γ产生.
  • 在体外生成的TIA细胞通过收养转移给感染了Legionella pneumophila的小鼠.

主要成果:

  • CD4 TIA细胞在各种疾病背景中被发现,这表明它在疾病中起着不可知性的作用.
  • 通过TCR和CD28刺激,天真的小鼠和人类CD4 T细胞可以通过TCR和CD28刺激分化为TIA细胞.
  • 通过收养转移的TIA细胞在体内L. pneumophila感染的先天性阶段显示出TCR独立的IFN-γ产生.

结论:

  • CD4 TIA细胞比以前认为的更为广泛.
  • 从天真的前体中诱导TIA细胞是可行的,为它们的生成提供了一个潜在的机制.
  • TIA细胞可能在各种疾病和感染中在免疫反应中发挥更广泛的作用.