新生儿高 bilirubinemia 中的补充: 随机对照试验的更新系统审查和元分析
Arushi Yadav1, Sivanesan Sivagnanaganesan, Jitendra Meena
1Author Affiliations: Department of Radiodiagnosis, Livasa Hospital, Sahibzada Ajit Singh Nagar, India (Dr A. Yadav); Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Drs Sivagnanaganesan, J. Yadav, J. Kumar); Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India (Dr Meena); and Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India (Dr Shamim).
The Journal of perinatal & neonatal nursing
|September 9, 2025
概括
口服补充剂可能会减少新生儿高白血症的光疗持续时间. 然而,它并没有显著影响其他关键结果,如胆红素水平或需要交换输血.
科学领域:
- 新生儿医学 新生儿医学
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
背景情况:
- 实验室研究表明,口服可以降低胆红素水平.
- 之前对用于新生儿超白血病的随机对照试验 (RCT) 显示了相互矛盾的结果.
- 需要巩固关于在治疗新生儿黄方面的疗效的证据.
研究的目的:
- 系统地评估口服补充剂对新生儿高 bilirubinemia 的影响.
- 评估对胆红素水平,光疗和不良事件的影响.
主要方法:
- 我们对PubMed,Embase,Web of Science和临床注册表进行了全面的搜索.
- 包括17项随机对照试验 (RCT),涉及1565名新生儿.
- 使用偏差风险版本2工具进行了随机效应元分析.
主要成果:
- 口服补充剂显著减少了光疗的平均持续时间8.6小时 (低确定性).
- 在显著的高白血症的发生率或需要光疗方面没有发现显著的差异 (确定性非常低).
- 在不良事件或住院时间方面没有观察到差异.
结论:
- 口服补充剂显示,有可能减少新生儿高 bilirubinemia 的光疗持续时间.
- 目前的证据表明,不会显著改变新生儿黄管理中的其他关键结果.
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