口腔同时感染多个阿尔法人类乳头瘤病毒和头癌风险
Mary T Amure1, Sreenath A Madathil1, Claudie Laprise1,2,3
1Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Quebec, Canada.
多次口腔人类乳头瘤病毒 (HPV) 感染显著增加头癌 (HNC) 的风险. 接种HPV疫苗有望减少HNC的发病率,特别是在那些没有感染疫苗向型HPV的人群中.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 加拿大与人乳头瘤病毒 (HPV) 相关的头癌 (HNC) 发病率上升.
- 关于多次口腔HPV感染在HNC病因学中的作用的不确定性.
- 关于HPV疫苗在减少HNC发病率方面的有效性证据有限.
研究的目的:
- 调查口腔HPV联合感染模式.
- 估计多种口腔HPV感染与HNC风险之间的关联.
- 评估消除针对疫苗的HPV基因型对HNC发病率的影响.
主要方法:
- 在蒙特利尔,对460个HNC病例和458个对照进行了病例控制研究.
- 对终身暴露数据进行面对面的采访.
- 对α-HPV基因型的口腔和癌症部位细胞进行PCR分析.
- 对于共感染和风险评估,Poisson和后勤回归.
- 针对性的最大概率估计,以模拟疫苗试验.
主要成果:
- 在HPV阳性个体中,34.76%的病例和31.15%的对照人群有多次口腔α-HPV感染.
- 多次口腔α-HPV感染与明显增加的HNC风险相关 (OR = 4.66).
- 接种HPV疫苗在一般人群和那些没有疫苗向HPV基因型的人群中显示出HNC风险的潜在降低.
结论:
- 多种口腔HPV感染很普遍,是HNC的重要危险因素.
- HPV 疫苗接种策略有望减少 HNC 的负担.
- 需要进一步的研究,以充分阐明HPV联合感染和疫苗接种对HNC的影响.
更多相关视频
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Cancer Prevention
Some...
Oral Cavity
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
