慢性精神分裂症中的高血糖血症:患病率,临床相关性,以及与症状严重程度的矛盾关联
Jianyan Du1, Rui Jiang1, Yuanyuan Liu1
1Tianjin Anding Hospital, Institute of Mental Health, Psychiatric Medical Center of Tianjin University, Mental Health Center of Tianjin Medical University, 13 Liulin Road, Tianjin, 300222, China.
过高homocysteinemia (HHcy) 影响超过一半的慢性精神分裂症患者,特别是年长的男性. 意想不到的是,高水平的homocysteine与较轻的精神分裂症症状相关,这表明存在复杂的关系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生化学
背景情况:
- 过高homocysteinemia (HHcy) 与精神分裂症的病理生理学有关.
- 之前的研究主要集中在早期精神分裂症,使得慢性精神分裂症中的HHcy研究不足.
- 这项研究调查了慢性精神分裂症中的HHcy患病率,决定因素和临床相关性.
研究的目的:
- 为了确定慢性精神分裂症患者中HHcy的患病率.
- 在这个人群中识别与HHcy相关的因素.
- 探索HHcy与临床特征之间的关系,包括症状严重程度和认知功能.
主要方法:
- 一项涉及中国509名慢性精神分裂症患者的横截面研究.
- 数据收集包括人口统计,临床,生活方式信息和生物化学参数.
- 标准化尺度 (PANSS,HAMD,ISI,RBANS) 评估了症状和认知;后勤回归确定了HHcy预测因素.
主要成果:
- 在慢性精神分裂症队列中,HHcy的患病率为56.2%.
- HHcy与年龄较大 (平均52.1岁) 和更高比例的男性 (67.1%) 有关.
- 较高的同类氨酸水平与较轻的积极和一般精神病理症状 (较低的PANSS分数) 和较高的CRP,TBIL和CPK水平相关.
结论:
- HHcy在慢性精神分裂症中非常普遍,特别是在老年男性中.
- 与假设相反,HHcy与该人群的症状严重程度降低有关.
- 这些发现表明,HHcy在慢性精神分裂症中的作用可能具有悖论性.
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