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Ambra Maddalon¹, Valentina Galbiati², Melissa Ferrian³

¹Laboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università Degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.

Archives of toxicology

|September 9, 2025

概括

草甘除草剂暴露改变了葡萄园工人的免疫反应,增加了Th2细胞因子,并降低了Th1/Th2细胞比率. 这表明与过敏反应的潜在联系,需要进一步调查.

科学领域:

环境健康环境健康
免疫毒理学免疫毒理学
职业健康职业健康职业健康

背景情况:

草甘是一种广泛使用的除草剂,正在审查潜在的不良健康影响,特别是对免疫系统的影响.
以前的研究表明,除草剂暴露与免疫失调之间存在联系,需要在职业环境中进一步研究.

研究的目的:

调查职业草甘暴露对葡萄园工人的免疫参数的影响.
在除草剂应用后识别细胞因子,T细胞亚群和microRNA水平的特定变化.

主要方法:

在草甘应用前后对26名葡萄园工人的队列进行了研究.
测量了血细胞因子水平 (IL-4,IL-5,IFN-γ,IL-8,IL-12/23p40,IL17,IL33),T细胞亚群,细胞外囊泡miR-500a和脂多糖.
计算和分析Th1/Th2细胞比率与细胞因子变化相关.

主要成果:

草甘暴露显著改变了血细胞因子的概况,因IL-4和IL-5的增加,IFN-γ的适度增加和IL-8的减少而显著改变.
观察到T辅助1/T辅助2细胞比率的显著下降,由减少的Th1和增加的Th2细胞驱动.
观察到细胞外囊泡miR-500a和血脂多糖化物水平的降低,这表明潜在的免疫调节和微生物群变化.

结论:

葡萄园工人暴露于草甘可以调节免疫系统,促进Th2偏差反应.
观察到的免疫变化可能会导致敏感个体过敏反应的风险增加.
这些发现强调需要进一步研究以确定因果关系并了解草甘免疫毒性作用背后的机制.

关键词:

细胞因子 (cytokines) 是一种细胞因子.草甘是一种天然的草甘.免疫调节是一种免疫调节.淋巴细胞淋巴细胞这就是米RNAs.职业暴露职业暴露

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