老年营养风险指数与扩散大B细胞淋巴瘤的预后之间的年龄相互作用

Kei Fujita^1,2, Hikaru Tsukasaki^1,3, Shin Lee^4,5

¹Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Annals of hematology

|September 9, 2025

概括

老年营养风险指数 (GNRI) 对扩散型大B细胞淋巴瘤 (DLBCL) 患者的整体存活率 (OS) 有显著影响. 年龄不会改变这种关联,这表明营养不良会对所有年龄组的生存率产生负面影响.

科学领域:

在瘤学瘤学.
老年病的医生老年病的医生
营养科学营养科学

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 是一种常见的非霍奇金淋巴瘤.
营养状况是影响癌症患者结果的关键因素.
老年营养风险指数 (GNRI) 是评估老年人营养风险的有效工具.

研究的目的:

研究GLBCL患者的GNRI和整体存活率 (OS) 之间的关联.
为了确定年龄是否改变了GNRI和OS之间的关系.
为了确定低GNRI的DLBCL患者营养不良的模式.

主要方法:

552名新诊断的DLBCL患者 (年龄≥18岁) 的多中心回顾性研究.
多变量考克斯回归与受限立方线 (RCS) 建模来评估GNRI和OS的关联.
分析年龄作为GNRI-OS关系的潜在修饰因素.

主要成果:

GNRI与OS显著相关,具有非线性关系 (P=0.0158).
年龄较大与较高的死亡风险有关.
低GNRI (<92) 预测不良的预后,无论年龄组,与营养不良的模式 (正常的白蛋白和BMI) 常见的~40%的这些患者.

结论:

由GNRI评估的营养不良会对所有年龄段的DLBCL患者的生存率产生不利影响.
年龄不会改变GLBCL中GNRI的预后影响.
低GNRI是DLBCL中低OS的重要预测因子,无论年龄如何.

关键词:

扩散大的B细胞淋巴瘤.效果修改影响修改老年人的营养风险指数.年长的成年人.年轻的成年人年轻的成年人

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