战争时期的压力和多发性硬化症患者的复发风险:一项前性队列研究
Roy Aloni1,2, Carmit Dror1,2, Tamar Barazani2
1Department of Psychology, Ariel University, Ariel, Israel.
Journal of neurology
|September 9, 2025
概括
战争时期的压力增加了多发性硬化症 (pwMS) 患者的复发率. 疲劳,而不是焦虑或抑郁,与复发有关,而应对灵活性并没有降低这种风险.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 心理压力是多发性硬化症 (MS) 疾病活动的潜在触发因素,但证据不一致.
- 以前的研究主要研究了慢性压力因素,对患有多发性硬化症 (pwMS) 个体如何应对战争等急性,大规模压力因素的理解有限.
研究的目的:
- 调查战时压力的影响,2023年10月7日袭击后,对pwMS的疾病活动的影响.
- 确定情绪因素是否与此期间的复发风险相关.
主要方法:
- 对2023年10月7日之前和之后的复发和残疾进展的临床数据的回顾性和前性收集.
- 在2024年4月至6月期间,向参与者提供了评估压力,焦虑,抑郁,疲劳和应对灵活性的问卷.
主要成果:
- 在发作后的一年中,38%的pwMS患者经历了至少一次复发,比前一年的23%有所增加.
- 更高的感知疲劳与复发有显著的关联;然而,焦虑,抑郁和感知压力没有显示出与复发频率有显著的联系.
- 应对灵活性并没有缓解心理痛苦对复发率的影响. 在这两个时期内,残疾进展保持稳定.
结论:
- 战时条件与pwMS中复发活动的增加相关.
- 疲劳可能表明在压力较大的时期,对MS复发的脆弱性增加.
- 测量的应对灵活性并没有减轻心理痛苦对复发风险的影响.
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