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NOTCH3驱动脂肪酸氧化和耐铁的抵抗在侵略性脑膜瘤

Nishanth S Sadagopan1,2, Mateo Gomez1,2, Shashwat Tripathi1,2

  • 1Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Journal of neuro-oncology
|September 9, 2025
PubMed
概括

NOTCH3信号传导通过促进脂肪酸氧化,耗尽脂质,并赋予对铁亡的抵抗力来驱动侵略性脑膜瘤. 这种代谢重编程突出了NOTCH3阳性瘤的潜在治疗漏洞.

关键词:
在NOTCH3中,脂肪酸氧化过程中的脂肪酸氧化.铁化是铁化的一种.脑膜瘤的新陈代谢瘤微环境是一个微环境.

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