Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Teratogenicity01:07

Teratogenicity

3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Neurulation01:30

Neurulation

44.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.

JAMA network open·2026
Same author

Structural and functional connectivity in infancy relate to communication skills at age 2 in children born very preterm.

medRxiv : the preprint server for health sciences·2026
Same author

Clinician Scientists in Occupational Therapy: Bridging the Knowledge-to-Practice Gap.

The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2026
Same author

Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.

Pediatrics·2026
Same author

Antenatal Opioid Exposure and Cerebral Cortical Maturation in Newborns.

JAMA network open·2026
Same author

Development and validation of a deep learning model for liver shear stiffness regression using abdominal multiparametric MRI across multiple sites and vendors.

European radiology·2026

相关实验视频

Updated: Jan 6, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K

在早产婴儿的历史性肌炎和神经发育.

Laura S Peterson1,2, Shalini Roy1,2, Viral G Jain3

  • 1Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

JAMA network open
|September 9, 2025
PubMed
概括

史学性肌膜炎 (HCA) 与早产婴儿的运动技能差异有关,这与早产独立. 这种炎症直接影响神经发育,表明需要向治疗.

更多相关视频

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.2K
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

297

相关实验视频

Last Updated: Jan 6, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.2K
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

297

科学领域:

  • 新生儿健康 新生儿健康
  • 神经发育儿科 神经发育儿科
  • 产科和妇科 产科和妇科

背景情况:

  • 胆膜炎增加了早产和潜在的神经发育障碍的风险.
  • 与神经发育问题的炎症相关的证据是不一致的.
  • 历史性肌膜炎 (HCA) 可能直接影响胎儿的神经发育超出早产期.

研究的目的:

  • 为了确定中度至严重的HCA是否与早产婴儿的不良运动性能直接相关.
  • 评估HCA对运动技能的独立影响,不包括早产的间接影响.
  • 调查早产在HCA-神经发育结果关系中的中介作用.

主要方法:

  • 对早产婴儿 (妊娠年龄 ≤32周) 的前性,基于人口的队列研究.
  • 在中度至重度HCA的婴儿和没有/轻度HCA的婴儿之间,比较了运动,认知和语言分数 (贝利婴儿和幼儿发展尺度,第三版).
  • 利用多变量回归和因果调解分析来评估直接和间接的关联.

主要成果:

  • 中度至重度的HCA独立地与22-26个月校正年龄的较低的运动,认知和语言分数相关.
  • 与对照组相比,患有HCA的婴儿的出生时间明显较早 (中位数为2.6周).
  • 因果调解分析表明,75%的运动缺陷是HCA的直接影响,25%是由早产早产调解的.

结论:

  • 中度至重度的HCA直接与早产婴儿的不良运动神经发育有关.
  • HCA通过诱导早产早产和通过直接的炎症作用影响神经发育.
  • 这些发现支持临床咨询和针对高风险怀孕的针对性抗炎干预措施.