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临床表现,触发因素,并发症和老年人过敏反应的管理:一项跨部门研究
Roy Khalaf1, Rawan Saleem1, Connor Prosty1
1Faculty of Medicine, McGill University, Montreal, Québec, Canada.
International archives of allergy and immunology
|September 9, 2025
概括
老年患者体验过敏反应的不同,有更多的药物/毒素触发物和更少的上腺素使用. 这凸显了对老年人过敏反应管理策略的需求.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 老年医学 老年医学
- 紧急医疗 紧急医疗
背景情况:
- 过敏反应是一种严重的系统性过敏反应,需要立即医疗照顾.
- 老年人群在识别和管理由于伴随疾病和改变生理反应的过敏反应方面存在独特的挑战.
研究的目的:
- 为了比较老年人 (≥65岁) 和非老年人之间的过敏反应触发因素,临床表现和管理.
- 确定优化老年人群中过敏反应护理的具体需求.
主要方法:
- 从跨加拿大过敏反应登记处 (C-CARE) (2011年4月至2024年5月) 追溯分析了1135例过敏反应病例.
- 使用基平方和非参数t测试,比较老年人和非老年人群之间的人口统计,触发因素,症状严重程度,并发症和药物使用情况.
主要成果:
- 与年轻人相比,老年患者 (7.9%) 的药物和毒素触发率更高 (p < 0.01) 和食物过敏率更低.
- 老年人的过敏反应在家中发生的频率更高 (p < 0.01),导致重症监护室 (ICU) 的入院率更高 (p = 0.04).
- 在老年患者中使用上腺素的频率明显低 (30.0%).
结论:
- 老年人经历不同的过敏反应概况,其特点是不同的触发因素和更高的严重结果需要ICU入院的可能性.
- 老年人较低的上腺素利用率强调了在及时和适当的过敏反应管理中存在的关键差距.
- 研究结果强调需要加强对老年人群过敏反应的识别,治疗坚持和个性化管理协议.
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