在SARS-CoV-2感染之前感知到的慢性压力预测了持续的症状COVID-19:一项前性队列研究
Christian Fazekas1, Nandu Goswami2,3, Franziska Matzer4
1Division of Medical Psychology, Psychosomatics and Psychotherapy, Department of Psychiatry, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Austria.
Psychotherapy and psychosomatics
|September 9, 2025
概括
在COVID-19感染之前感知较高的慢性压力增加了一个月后经历持续症状的可能性. 这一发现强调了压力是COVID-19进展和长期COVID发展的关键因素.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 慢性压力是严重COVID-19的潜在风险因素之一.
- 了解这种联系可以为公共卫生战略和个性化干预提供信息.
- 这项研究调查了感染前慢性压力对COVID-19症状持续性的影响.
研究的目的:
- 为了确定先前存在的慢性压力是否会影响正在进行的症状性COVID-19的发展.
- 为了确定持续COVID-19症状的一个月后感染后的预测因素.
主要方法:
- 最近感染SARS-CoV-2的成年人的前性队列研究 (StressLoC).
- 使用感知压力尺度 (PSS-10),压力生活事件和头发皮质醇评估了先前存在的慢性压力.
- 定义的结果是持续的COVID-19症状在1个月使用长COVID症状和影响工具.
主要成果:
- 该队列包括288名参与者; 72.9%的人正在进行COVID-19 (OSC-G) 症状.
- 在感染之前感知到的慢性压力 (PSS-10) 显著预测了OSC-G分配 (OR:1.08,p=0.002).
- 预先存在的症状数量也预测了OSC-G (OR:1.08,p=0.001);压力生活事件和头发皮质醇没有.
结论:
- 提高先前存在的感知慢性压力与增加患有持续症状COVID-19的几率有关.
- 感知到的压力,而不是其他压力标志物,成为一个重要的预测因素.
- 研究结果表明,压力管理对于减轻长期COVID风险至关重要.
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