在患有状细胞疾病的儿童中对肺炎球菌的疫苗免疫:一项回顾性单中心研究
Clara Noble1,2, Renato Gualtieri2,3, Veneranda Mattiello4
1From the Faculty of Medicine.
The Pediatric infectious disease journal
|September 9, 2025
概括
患有状细胞疾病 (SCD) 的儿童在初次接种疫苗后大约五年需要肺炎球菌疫苗增剂. 这确保了对侵入性肺炎球菌病的持续保护.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 患有状细胞疾病 (SCD) 的儿童面临侵入性肺炎球菌疾病的风险增加.
- 疫苗接种和青素预防是这一脆弱群体的关键预防策略.
- 对于患有SCD的儿童,最佳的肺炎球菌再接种计划尚未确定.
研究的目的:
- 评估高收入国家SCD儿童肺炎球菌疫苗接种情况和血清保护.
- 评估遵守国家疫苗接种指南及其有效性.
- 分析增强剂对疫苗长期免疫力的影响.
主要方法:
- 对2009年至2023年期间诊断出SCD的42名儿童电子病历的回顾性审查.
- 对临床,人口统计数据和肺炎球菌血清学结果的分析.
- 卡普兰-梅尔分析以评估随时间推移的血清保护.
主要成果:
- 81%的患者有疫苗接种记录,所有患者都完成了适合年龄的疫苗接种计划.
- 44%的受试者至少服用了一剂强剂,平均年龄为3.47岁.
- 在初级疫苗接种系列之后,血清保护在5岁后显著下降.
结论:
- 对于患有SCD的儿童,初级疫苗系列完成后大约5年,可能需要进行肺炎球菌疫苗强剂.
- 需要进一步的前性研究来确定最佳的增强剂频率,并确定影响免疫力下降的因素.
- 这项研究强调了在儿科SCD管理中需要改进的疫苗接种策略.
相关概念视频
Vaccinations
51.3K
Overview
51.3K
Pneumonia III: Complications and Assessment
792
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
792
Sputum Studies II: Culture and Sensitivity
1.1K
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
1.1K
Pneumonia II: Pathophysiology
2.6K
The pathophysiology of pneumonia involves the following steps:
2.6K
Pneumonia I: Introduction
749
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
749


