预测癌症患者的死亡动态:一种机器学习方法来预测死亡事件
Tatsuki Yamamoto1, Minoru Sakuragi1,2, Yuzuha Tuji1
1Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
PloS one
|September 9, 2025
概括
分析电子健康记录的机器学习模型揭示了临死临近的不同患者状态. 这种方法提高了对终末期疾病进展的理解,并个性化了终身护理策略.
科学领域:
- 计算生物学是一种计算生物学.
- 医疗信息学医学信息学
- 在瘤学瘤学.
背景情况:
- 了解临近死亡的患者内部状态的变化对于改善生命终端护理至关重要.
- 当前的方法往往缺乏对不断变化的状态的全面了解,只关注特定标记.
研究的目的:
- 开发和应用机器学习模型,用于对患者死亡前的状态进行时间分析.
- 通过使用电子健康记录数据,识别不同临床模式和末期疾病进展的亚型.
主要方法:
- 分析了8976名癌症患者的电子健康记录 (EHR) 数据,使用77个实验室参数.
- 使用渐变增强决策树构建连续死亡率预测模型.
- 利用Shapley添加式扩展 (SHAP) 进行时间特征分析和患者分层.
主要成果:
- 在临近死亡的患者中确定了三种不同的临床模式.
- 专和C反应蛋白等关键实验室参数对死亡率预测有显著的贡献.
- 基于SHAP的患者分层比传统方法更有效地捕捉疾病进展的隐藏变异.
结论:
- 机器学习驱动的时间分析揭示了传统方法错过的临床上有意义的状态过渡.
- 这一框架为终端疾病进展的异质性提供了新的见解.
- 增强个性化的风险分层和优化终身护理策略的潜力.
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