在母亲遗传的共生体中,细胞质不相容基因的多样性和传播
Julien Amoros1, Marie Buysse1, Anna Maria Floriano2
1MIVEGEC, University of Montpellier, CNRS, IRD, Montpellier, France.
PLoS genetics
|September 9, 2025
概括
以前与Wolbachia相关的细菌 cifA-cifB 基因对在各种细菌内共生生物和病原体中广泛存在. 这一发现表明细胞质不相容性 (CI) 可能在关节动物的繁殖和疾病传播中发挥更广泛的作用.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 进化生物学 进化生物学
背景情况:
- 细胞质不相容性 (CI) 是关节动物的生殖机制,通常由Wolbachia细菌属介导.
- 众所周知,沃尔巴基亚的 cifA-cifB 基因对通过破坏关节动物胚胎发育来引起CI.
- 沃尔巴基亚以外的 cifA-cifB 基因对的分布和功能在很大程度上仍未被探索.
研究的目的:
- 研究 cifA-cifB 基因对在广泛的细菌内共生生物及其亲属中的流行程度和多样性.
- 探索 cifA-cifB 基因对在非Wolbachia 细菌系中的潜在作用及其对关节动物生物学和疾病动态的影响.
主要方法:
- 对762种细菌基因组进行全基因组调查,包括非沃尔巴基亚内共生生物和相关物种.
- 生物信息分析以确定 cifA-cifB 基因同类物和保存的功能动机 (PD(D/E) -XK 核酶,AAA-ATPase).
- 遗传学分析以推断水平基因转移事件和移动遗传元素的作用.
主要成果:
- cifA-cifB基因对在8.4%的被调查基因组中被发现,特别是在17.4%的选择性共生体中.
- 在8个细菌属中发现了Cif位点,这些细菌属分为多种类型 (α-Proteobacteria, γ-Proteobacteria, Mollicutes, Bacteroidota) 的8个细菌属,超越了Wolbachia.
- 保存的结构动图和在移动遗传元素 (转子体,先导体) 中的频繁整合表明水平转移.
- 在关节动物病原体中发现了Cif存在,这意味着它在载体传播疾病传播中的作用.
结论:
- cifA-cifB基因对和相关的CI在细菌种群中比以前理解的更广泛.
- 由移动遗传元素促进的水平基因转移可能有助于CIF基因的传播.
- CI的更广泛分布对理解关节动物的繁殖策略,共生和载体传播疾病的流行病学有重大影响.
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