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确定与随后诊断上腺腺瘤相关的因素:基于人口的历史病例控制研究
Ashley J Han1, Sara J Achenbach2, Elizabeth J Atkinson2
1Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, United States.
肥胖,低社会经济地位,吸烟和糖尿病与上腺腺瘤有关. 体重指数 (BMI) 增加和吸烟独立地增加患上上腺腺瘤的几率.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 上腺瘤是常见的,通常是无症状的瘤.
- 识别可修改的风险因素对于预防和早期检测至关重要.
研究的目的:
- 调查与上腺腺瘤诊断相关的社会和代谢风险因素.
- 确定这些因素的独立预测值.
主要方法:
- 基于人口的历史病例控制研究设计.
- 病例:成年患者被诊断患有上腺腺瘤 (2005-2017年).
- 控制组:年龄和性别匹配的个体,没有上腺腺瘤,先做成像.
主要成果:
- 在诊断前5-10年观察到的肥胖,低社会经济地位,吸烟和糖尿病的更高患病率.
- 增加的体重指数 (BMI) (OR 1.18,95% CI 1.07-1.32) 和吸烟 (OR 1.41,95% CI 1.06-1.87) 独立地与增加上腺瘤的几率有关.
- 对于高血压,物质使用,慢性脏病或心血管事件没有发现显著的关联.
结论:
- 肥胖,低社会经济地位,吸烟和糖尿病是上腺腺瘤的重要危险因素.
- 增加的BMI和烟草使用是上腺腺瘤诊断的独立预测因素.
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