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尽管在加拿大多伦多的一个队列中接受了tecovirimat治疗,但麻疹病毒的流放仍在增加
Jacklyn R Hurst1, Mary Addo2, Abby Li3
1Biological Sciences, Sunnybrook Research Institute, Sunnybrook Hospital, Toronto, Ontario, Canada.
The Journal of infectious diseases
|September 9, 2025
概括
在多伦多的一项研究中,Tecovirimat (TPOXX) 并没有显著减少来自皮肤病变的传染性麻疹病毒 (MPXV) 脱落. 在接受治疗和未接受治疗的个体中,MPXV泄漏的持续程度相似,这表明需要使用替代抗病毒策略.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 德科维里马特 (TPOXX) 是加拿大授权的mpox抗病毒药物.
- 最近的临床试验表明TPOXX对POX症状持续时间没有影响.
研究的目的:
- 评估特科维里马特对从皮肤病变中脱落的传染性水病毒 (MPXV) 的影响.
- 评估病毒分泌动力学,并确定mopox患者的抗病毒耐药性突变.
主要方法:
- 在多伦多对17名被诊断为mopox的个人进行前性队列研究.
- 通过细胞培养,每周对感染性MPXV进行分析的皮肤病变扫描.
- 通过PCR和F13L基因的测序来检测抗病毒耐药性突变.
主要成果:
- 在31%的tecovirimat治疗和32%的未接受治疗的参与者中检测到传染性MPXV分泌.
- 发泄动力学在两组之间是相似的,在几个个体中,持续发泄超过两周.
- 四名接受治疗的参与者在开始使用tecovirimat后的15天内流失了活力病毒;没有发现抗药性突变.
结论:
- 德科维里马特并没有显著改变皮肤病变传染性MPXV脱落的持续时间.
- 这些发现与最近的试验结果一致,表明TPOXX在这种情况下的临床疗效有限.
- 建议使用替代抗病毒疗法和持续的基因组监测以检测耐药性.
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