在一项随机临床试验中,通过直肠和腹膜前列腺活检后,参与者报告的结果措施
Adrian J Waisman Malaret1, Paul J Feustel2, Fortis Gaba1
1Department of Urology, Albany Medical Center, Albany, New York.
The Journal of urology
|September 9, 2025
概括
甲经前列腺活检 (TP-Bx) 比甲经前列腺活检 (TR-Bx) 引起更多的疼痛和尿道问题. 这些发现对于为患者提供有关前列腺活检程序的咨询至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 外科手术的结果
- 患者报告的结果
背景情况:
- 患者报告的结果测量 (PROM) 对于医疗干预建议至关重要.
- 跨直肠活检 (TR-Bx) 和跨膜活检 (TP-Bx) 后对PROM进行前性比较研究是有限的.
研究的目的:
- 进行TR-Bx和TP-Bx之间的PROM的比较分析.
- 评估前列腺活检患者报告的疼痛和功能结果.
主要方法:
- 一项随机试验 (ProBE-PC) 在局部麻醉下比较TR-Bx和TP-Bx.
- 收集参与者报告的疼痛评分 (数值评分表) 和功能结果 (IPSS,IPSS-QoL,IIEF-5).
- 对临床上显著的疼痛 (得分≥4) 和功能性得分中临床上最小重要的变化进行分析.
主要成果:
- 与TR-Bx相比,TP-Bx在多个时间点与明显更高的疼痛得分相关.
- 临床上显著的疼痛在LA注射期间和手术的晚上更频繁地与TP-Bx.
- 增加的尿功能障碍 (IPSS和IPSS-QoL恶化) 在TP-Bx后比TR-Bx后更频繁地报告.
结论:
- 与TR-Bx相比,TP-Bx导致更高的疼痛率和疼痛水平.
- 接受TP-Bx治疗的患者在术后经历了尿路功能障碍的增加.
- 这些发现对于有关前列腺活检选择的患者咨询具有临床意义.
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