用片向的纳米粒子用于瘤治疗.
Valeria Sidorenko1, Allan Tobi2, Kazuki N Sugahara3
1Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, 50411 Tartu, Estonia; Division of GI/Endocrine Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
概括
瘤定位可以通过向特定的分子标记物来增强纳米粒子 (NP) 向固体瘤的传递. 这种有针对性的方法可以改善药物积累和治疗结果,同时最大限度地减少非目标毒性.
科学领域:
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
- 在瘤学瘤学.
背景情况:
- 化疗药物通常会由于非特异性分布而导致非目标毒性.
- 纳米粒子 (NP) 配方可以改善药物输送,但在透固体瘤方面面临挑战.
- 瘤微环境对有效的NP输送构成重大障碍.
研究的目的:
- 审查瘤定位的应用,以增强NP向固体瘤的输送.
- 探索这些酸如何克服瘤微环境障碍.
- 评估对治疗结果和降低毒性的影响.
主要方法:
- 关于瘤定位和NP输送系统的文献综述.
- 对类向机制和瘤透策略的分析.
- 评估表明改善瘤积累和治疗疗效的研究.
主要成果:
- 瘤定位可以通过与特定的分子标记物结合,促进瘤中针对性的NP积累.
- 瘤透可以增强NP的扩散和透到瘤表皮质.
- 通过类的向输送显著减少了与非特定方法相比的非向效应.
结论:
- 瘤定位是一种有前途的策略,可以提高基于NP的癌症疗法的疗效.
- 胺介导的输送克服了在深入实体瘤中到达瘤细胞的关键挑战.
- 这种方法有可能改善治疗结果并降低患者的毒性.
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