传播的Mycobacterium simiae感染导致严重免疫缺陷患者的鼻炎
Christoffel Opperman1, Nectarios Papavarnavas2, Sally Candy3
1National Health Laboratory Service, Green Point TB-Laboratory, Cape Town, South Africa; SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
概括
本病例报告详细介绍了第一例引起鼻炎的Mycobacterium simiae (M. simiae) 的病例. 它强调了这种环境非结核菌 (NTM) 在免疫受损个体中带来的严重风险.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 免疫功能受损的宿主病理
背景情况:
- 菌根菌 (M. simiae) 是一种环境非结核菌 (NTM),通常在土壤和水中发现.
- 虽然M. simiae感染很少见,通常是肺外感染,但它的临床意义正在增长.
- 之前没有记录过由M. simiae引起的鼻炎.
研究的目的:
- 报告第一个由Mycobacterium simiae引起的鼻炎病例.
- 为了说明M. simiae在严重免疫受损的个体中引起破坏性疾病的潜力.
主要方法:
- 一个33岁的男性的病例介绍,患有先进的艾滋病毒和先前的结核病治疗.
- 诊断方法包括成像 (带有骨质侵蚀的鼻腔模糊),血液和鼻腔吸附培养.
- 使用线式探针试验证实了Mycobacterium simiae的鉴定.
主要成果:
- 患者呈现出,眼睛疼痛,发烧和鼻水.
- 图像检测显示,阴道模糊化与轨道骨质侵蚀.
- 在血液和鼻吸附培养物中发现了Mycobacterium simiae.
- 尽管多学科的护理,患者经历了最小的改善,并屈服于感染.
结论:
- 这一案例是首次记录有M. simiae相关鼻炎的案例.
- 它强调了环境NTM在引起破坏性和传播性疾病方面的致病潜力.
- 严重免疫功能低下的患者面临严重NTM感染的显著风险.
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