严重的eosinophilic胃炎与外围eosinophilia和多器官参与有关
Xintong Wang1, Yansheng Hao2, Hansen Lam3
1Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human pathology
|September 9, 2025
概括
组织学性胃异osinophilia (HGE) 经常出现胃,并与儿童的食物过敏和成年人的药物过敏有关. 严重的HGE与外围阴和多器官肠道干扰相关,有助于临床随访.
科学领域:
- 胃肠病学 胃肠病学
- 过敏和免疫学 过敏和免疫学
- 病理学 病理学 病理学
背景情况:
- 基因组性胃异osinophilia (HGE) 是一个研究不足的疾病,原因不清楚.
- 诊断标准,包括埃诺菲尔值和内镜检测结果,对于HGE来说并不清楚,与埃诺菲尔食道炎 (EoE) 不同.
研究的目的:
- 在儿童和成人群体中调查HGE的临床,组织学和内镜特征.
- 为了比较儿童和成年人之间的HGE特征,以及不同严重程度之间的特征.
主要方法:
- 50名被诊断患有HGE的患者的回顾性分析.
- 对HGE病例的分层划分为G1 (50-100埃索诺菲尔/HPF) 和G2 (>100埃索诺菲尔/HPF) 严重程度组.
- 基于年龄组和HGE严重程度的临床和组织学特征的比较.
主要成果:
- 大多数HGE患者 (70%) 有过敏/皮病史.
- 儿童患者更有可能患有食物过敏,而成年人患药物过敏的比例更高.
- 胃/侵蚀是最常见的内镜发现 (34.0%),而40.9%的患者患有多器官胃肠道干扰.
- 严重的HGE (G2) 与较轻度的HGE (G1) 相比,与较高的外围阴和多器官GI参与率有关.
结论:
- HGE经常以胃的形式出现,并且与基于年龄的特定过敏有关.
- 严重的HGE表明有更高的系统性埃索诺菲尔参与的可能性,指导临床管理和随访.
- 需要进一步的研究来阐明病因学,并建立HGE的标准化诊断标准.
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