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Updated: Jan 18, 2026

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
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MKRN2在通过宿主微环境和巨细胞M1到M2开关调节瘤生长中的新型作用

Jian-Ge Qiu1, Peng Sang2, Feng-Mei Zhou3

  • 1Department of Radiology, Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, 450002, China; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.

Cancer letters
|September 9, 2025
PubMed
概括

马科林-2 (MKRN2) 通过控制巨细胞极化和炎症来调节瘤微环境 (TME). 失去MKRN2会加速瘤的生长,并恶化患者的生存率,突出其作为癌症生物标志物和治疗点的潜力.

关键词:
COX2二氧化碳的使用.癌症 癌症 癌症 癌症在MKRN2中,MKRN2是MKRN2.在 NF-κBB 中.瘤的免疫微环境

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