社会经济差异和刺激性肠综合征的风险:一个队列研究与调解分析
Yesheng Zhou1, Si Liu1, Qian Zhang1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; State Key Laboratory of Digestive Health, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing, China; Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
更高的社会经济地位 (SES) 与患上易怒肠综合征 (IBS) 的风险较低有关. 健康的生活方式显著调解了这种保护性关联,这表明联合干预可以减少IBS的发生率.
科学领域:
- 胃肠病学和公共卫生
背景情况:
- 社会经济地位 (SES) 是健康结果的关键决定因素.
- 刺激性肠综合征 (IBS) 是一种普遍存在的胃肠疾病,具有多因素的病因.
- SES,生活方式和IBS风险之间的相互作用需要进一步调查.
研究的目的:
- 检查社会经济地位 (SES) 与发生刺激性肠综合征 (IBS) 的风险之间的关联.
- 评估健康生活方式因素在SES和IBS风险之间关系中的调解作用.
主要方法:
- 一个前性收集的353790名最初没有IBS的参与者的队列的回顾性分析.
- 通过收入,教育和就业的潜在阶级分析来评估SES.
- 健康生活方式得分来源于吸烟,酒精,饮食,体力活动,BMI和睡眠.
- 采用了考克斯的比例危险模型和顺序调解分析.
主要成果:
- 较高的SES模式与明显较低的发生IBS风险相关 (HR 0.61).
- 健康的生活方式调解了SES-IBS风险关联的10.2%.
- 更高的收入,教育程度和就业状况单独减少了IBS风险8%-32%.
- 与低SES/不健康生活方式组相比,高SES和健康生活方式的个体有55%的IBS风险降低.
结论:
- 较高的社会经济地位独立地与患IBS风险降低有关.
- 健康的生活方式因素在这种保护作用中起着重要的调解作用.
- 公共卫生战略应解决SES差异,并促进健康的生活方式,以减轻IBS的负担.
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