激发性和抑制性影响的汇聚和分离在前腔室的thalamic核中
László Biró1, Zsolt Buday2,3, Kata Kóta2,3
1Lendület Laboratory of Thalamus Research, HUN-REN Institute of Experimental Medicine, Budapest 1083, Hungary biro.laszlo@koki.hu acsady@koki.hu.
副腹腔核 (PVT) 具有独特的输入组织,在其核心区域接收多种激发和抑制信号. 这种结构可以解释其在处理情感行为的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 塔拉米细胞核研究研究
- 情感行为研究 情感行为研究
背景情况:
- 副腹腔体核 (PVT) 对于整合兴奋,压力,成和焦虑信号至关重要.
- 虽然PVT活动对动机,成和平衡有深远的影响,但其关联组织的理解很少.
研究的目的:
- 阐明皮质下刺激和抑制输入到PVT的来源,分布和整合.
- 为了研究PVT的皮质输入的特定层组织.
主要方法:
- 利用转基因雄性和雌性小鼠进行细胞类型和层特定向.
- 分析了来自下丘脑和脑干区域的GABAergic和glutamatergic神经元输入.
- 检查了来自中部前额叶皮质的特定层的皮质 afferents.
主要成果:
- 与其他胸膜核相比,PVT表现出独特的输入组织.
- 接收了各种各样的皮质下刺激和抑制输入,其中大多数针对的是卡莱丁宁阳性 (CR +) 核心.
- 皮层输入显示了层特定的分离,第5层针对CR+核心,第6层针对过渡区.
结论:
- CR+PVT核心接收到来自第5层的融合激发和抑制输入以及强大的自上而下的控制.
- 这种独特的组织将CR + PVT核心定位为情感行为的关键沟通瓶.
更多相关视频
10:31In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
Published on: August 18, 2020
09:49Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
Published on: April 15, 2016
相关概念视频
Diencephalon: Thalamus and Information Relay
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Diencephalon: Anatomical Regions
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Integration of Synaptic Events
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
