运动和营养干预在肝硬化萨尔科佩尼亚:一个系统的审查和随机对照试验的网络元分析随机对照试验
Sirinda Kittiprachakul1, Soe Thiha Maung2,3, Napalai Poorirerngpoom4
1Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
European journal of clinical nutrition
|September 9, 2025
概括
运动是治疗肝硬化患者的缩症的关键. 将运动与蛋白质和分支链氨基酸 (BCAA) 补充剂相结合,最有效地增加肌肉质量,而补充剂本身不会改善肌肉.
科学领域:
- *肝病学和老年医学
- * 临床营养和运动生理学
背景情况:
- * 标志着肌肉损失的肉,在肝硬化中很常见,并且与患者不良结果有关.
- *有效的治疗肝硬化性sarcopenia对于改善患者预后至关重要.
研究的目的:
- * 评估运动,蛋白质和分支链氨基酸 (BCAA) 补充剂在治疗肝硬化症中沙症的疗效.
- * 为了比较这些干预措施对肌肉质量,力量和身体表现的影响.
主要方法:
- *对23项涉及1525名参与者的随机对照试验进行了系统审查和网络元分析 (NMA).
- *包括的研究评估了运动,蛋白质和/或BCAA补充剂对萨科佩尼亚特征的评估.
- *计算了具有95%置信区间 (CI) 的标准化平均差异 (SMD).
主要成果:
- *与蛋白质和BCAA补充剂相结合的运动显示肌肉质量增加最大 (SMD 2.12).
- *单独运动或与补充剂一起也改善了肌肉质量;单独补充剂没有.
- * 运动显著提高了体力表现 (SMD 1.43),运动加蛋白质超过了单纯的蛋白质.
结论:
- * 运动是肝硬化中肉类的主要治疗方法,与蛋白质和BCAA补充剂相结合时最有效.
- * 营养补充剂本身并不能改善这一群体的肌肉质量.
- * 需要进一步的研究,以确定肝性sarcopenia的最佳运动方案.
相关概念视频
01:27Exercise and Muscle Performance
2.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.3K
01:26Atherosclerosis III: Management
322
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
322
01:29Chronic Pancreatitis II: Collaborative Care
317
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
317