轻度认知障碍影响功能性大脑连接与多发性硬化症或没有多发性硬化症的老年人认知的关联
Siddharth Nayak1, Mark E Wagshul2,3, Roee Holtzer4,5
1Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. siddharth.nayak@einsteinmed.edu.
GeroScience
|September 9, 2025
概括
患有多发性硬化症 (MS) 的老年人的认知功能与大脑连接有关. 轻度认知障碍 (MCI) 改变了这种关系,影响了MS患者的神经机制.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 认知能力下降是多发性硬化症 (MS) 的常见挑战,但其潜在的神经基础仍然不完全理解.
- 研究静止状态功能连接 (RSFC) 提供了对老化和神经疾病中的大脑网络动态的见解.
研究的目的:
- 为了检查轻度认知障碍 (MCI) 如何影响RSFC与老年人MS (OAMS) 认知功能之间的关联,与健康对照相比.
主要方法:
- 使用磁共振成像 (MRI) 进行RSFC评估和认知测试,特别是口腔符号数字模式测试 (SDMT).
- 使用多个线性回归来分析RSFC网络与SDMT性能之间的关系,包括使用MCI进行调节分析.
主要成果:
- 在整个队列中,在传感动力,左侧前端对称和突出网络中,更高的RSFC与更好的SDMT性能相关.
- 在OAMS中,在中间视觉和感觉运动网络中发现了显著的积极关联.
- 在后置默认模式和OAMS中的皮层下网络中,MCI调节了RSFC-SDMT关系.
结论:
- 在特定的大脑网络中增强的RSFC与衰老中更好的认知功能有关.
- 在老年人中,MS和MCI的存在显著改变了大脑连接和认知表现之间的关系.
关键词:
在前面的平行线上.功能连接性的功能连接性.多发性硬化症是多发性硬化症.SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT突出 突出 突出 突出更多相关视频
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