"X-Age项目"旨在建造一个中国老化的时钟
Jiaming Li1,2, Mengmeng Jiang1,3, Qiaoran Wang1,2
1Aging Biomarker Consortium (ABC), Beijing, China.
Nature aging
|September 9, 2025
概括
X-Age项目旨在为中国人口开发衰老时钟,以评估生物年龄和识别衰老生物标志物. 这一倡议将有助于了解衰老和评估针对日益增长的老年人口的干预措施.
科学领域:
- 老年学是一门学科.
- 生物标志物发现发现
- 人口健康 人口健康
背景情况:
- 全球人口正在快速老龄化,特别是在中国,这增加了与年龄有关的疾病对医疗保健系统的负担.
- 老龄化生物标志物联盟 (ABC) 发起了X-Age项目,以应对中国人口老龄化的独特挑战.
- 了解生物年龄对于管理与年龄相关的健康问题和制定有针对性的干预措施至关重要.
研究的目的:
- 为中国人口开发一个全面的老龄化评估系统.
- 为了确定强大的生物标志物老化和构建复合老化钟.
- 为了捕捉和分析不同中国人群的生物年龄.
主要方法:
- 招募多元化的中国队伍.
- 生物样本的标准化采集.
- 多模式数据采集,包括omics和临床数据.
- 基于机器学习的老化时钟模型的开发.
主要成果:
- 该项目旨在确定关键的衰老生物标志物.
- 开发针对中国人口的经过验证的复合老龄化时钟.
- 建立一个评估生物年龄及其异质性的平台.
结论:
- "X-Age"项目将为了解中国的老龄化提供一个可扩展的平台.
- 它将促进早期发现加速衰老和评估干预措施.
- 这项研究对于调整医疗保健策略以适应人口老龄化至关重要.
相关概念视频
Setting Time of Cement
600
The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...
600
Generation Time
1.4K
Bacterial generation time, the period required for a bacterial population to double during its exponential growth phase, serves as a critical measure of microbial growth dynamics under optimal conditions. This parameter varies significantly across bacterial species and can be influenced by factors such as temperature, pH, and the availability of nutrients. For example, Escherichia coli can achieve a generation time of approximately 20 minutes, while Mycobacterium tuberculosis exhibits a much...
1.4K
Aging
613
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
613
The X̄ Chart
448
The x̄ chart is a statistical tool for monitoring the means in a process.
The x̄ chart, often known as the individual control chart, is a crucial tool in statistical process control. It is designed to monitor process behavior and performance over time and is widely used in various industries to ensure that processes are operating at their optimum capacity and within specified limits.
A x̄ chart is constructed by plotting individual measurements of a quality...
The x̄ chart, often known as the individual control chart, is a crucial tool in statistical process control. It is designed to monitor process behavior and performance over time and is widely used in various industries to ensure that processes are operating at their optimum capacity and within specified limits.
A x̄ chart is constructed by plotting individual measurements of a quality...
448
Torsional Pendulum
7.1K
A torsional pendulum involves the oscillation of a rigid body in which the restoring force is provided by the torsion in the string from which the rigid body is suspended. Ideally, the string should be massless; practically, its mass is much smaller than the rigid body's mass and is neglected.
As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played...
As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played...
7.1K


