在服用氧化chloroquine的患者中评估质细胞复合体
Prativa Acharya1, Pragati Gautam Adhikari2, Ranju Kharel Sitaula2
1Department of Ophthalmology, Institute of Medicine, Tribhuvan University, B.P Koirala Lions Centre For Ophthalmic Studies, Kathmandu, Nepal. prativaa10@gmail.com.
BMC ophthalmology
|September 9, 2025
概括
氧化的使用与减少团细胞复合体 (GCC) 厚度和增加视网膜层体积损失有关. 无论氧化治疗的持续时间如何,都观察到这种效应.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜成像 视网膜成像
- 药理学研究 药理学研究
背景情况:
- 氧化广泛用于自身免疫性疾病.
- 需要监测氧化对眼睛的潜在毒性.
- 评估对视网膜结构的影响对于患者安全至关重要.
研究的目的:
- 为了评估使用氧化的患者的细胞复合体 (GCC) 厚度.
- 为了研究氧化使用时间和GCC厚度之间的关系.
- 量化氧化使用者的视网膜层体积损失.
主要方法:
- 一项基于医院的横截面研究涉及87名接受氧化的患者和年龄/性别匹配的对照.
- 进行了眼科评估和扩张 fundus 检查.
- 扫描源OCT (RTvue XR Avanti SD-OCT) 测量了平均,上层和下层GCC厚度以及焦点/全球损失体积.
主要成果:
- 与对照组相比,服用氧化的患者的平均,上下GCC厚度显著降低 (p < 0.001).
- 在接受氧化的患者中观察到焦损体积 (FLV) 和全球损失体积 (GLV) 的增加.
- 在GCC厚度和氧化摄入时间之间没有发现统计学意义上的相关性.
结论:
- 氧化使用导致团细胞复合体显著稀薄.
- 增加的FLV和GLV表明与氧化相关的视网膜层损伤.
- 建议对长期接受氧化治疗的患者进行定期的眼科监测.
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