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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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开发和外部验证白衣高血压的多变量预测模型.

Shali Hao1, Xiaomei Zhang2, Lingxiao Li1

  • 1Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (the First People's Hospital of Shunde), Foshan, China.

Journal of evidence-based medicine
|September 10, 2025
PubMed
概括
此摘要是机器生成的。

一个新的预测模型使用临床数据帮助识别白衣高血压 (WCH) 和持续高血压 (SH). 这种工具有助于个性化血压管理,减少了对广泛的办公室外监测的需求.

关键词:
这个名字是名ogramogram.预测模式 预测模式持续的高血压持续的高血压.白外套高血压是什么意思

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科学领域:

  • 心脏病学 心脏病学
  • 高血压研究 高血压研究
  • 临床预测建模模型

背景情况:

  • 白袍高血压 (WCH) 诊断需要在办公室外监测血压 (BP),这是资源密集的.
  • 使用随时可用的临床数据开发预测模型可以简化WCH识别.

研究的目的:

  • 根据患者的临床特征,开发和验证用于识别白衣高血压 (WCH) 的预测模型.
  • 创建一个工具,帮助临床医生区分WCH和持续高血压 (SH).

主要方法:

  • 使用多变量逻辑回归对233名门诊患者的临床数据进行了预测模型的开发.
  • 确定了WCH的独立预测因子,并构建了一个名ogram.
  • 该模型在一个独立的研究站点对150名患者进行了外部验证.

主要成果:

  • 确定了WCH的六个关键预测因素:办公室缩血压,体重指数,性别,总胆固醇,同氨酸和心率.
  • 预测模型在训练组中达到0.792的AUC,在外部验证组中达到0.692的AUC.
  • 校准和决策曲线分析证实了该模型在区分WCH和SH方面表现良好.

结论:

  • 开发的预测模型有效地使用临床数据识别了WCH的个体.
  • 这个工具可以指导针对异常血压的个性化管理策略.
  • 它提供了一种更有效的方法,而不是仅仅依靠办公室外的BP监控.