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Updated: May 12, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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对于cMoL的急性毒性和基因毒性,cMoL是一种来自Moringa oleifera种子的莱,具有对加密球菌菌株的抗真菌活性

Matheus Cavalcanti de Barros1, Sávia Soraia Santana da Silva1, Eduarda Pinto Gagliano1

  • 1Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

Journal of applied toxicology : JAT
|September 10, 2025
PubMed
概括

凝固剂Moringa oleifera lectin (cMoL) 对Cryptococcus种类表现出强大的抗真菌活性. 这种天然化合物是安全的,在小鼠中没有观察到毒性或基因毒性,这表明它有可能成为一种新的抗真菌疗法.

关键词:
抗真菌蛋白是一种抗真菌蛋白质.抗微生物药物莱克的使用.这种疾病叫做cryptococcosis.毒理学 毒理学 毒理学

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...