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Updated: Jan 18, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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帕金森病的遗传修饰者:一个病例对照研究

Matthew J Kmiecik1, Michael V Holmes1, Pierre Fontanillas1

  • 123andMe, Inc., Sunnyvale, California, USA.

Annals of clinical and translational neurology
|September 10, 2025
PubMed
概括

像LRRK2 p.G2019S和GBA1 p.N409S这样的遗传因素显著影响帕金森病 (PD) 的风险和症状. 多基因风险评分 (PRS) 和APOE E4也影响PD透率和呈现.

关键词:
在 GBA1 中,GBA1 是 GBA1 的代名词.这是LRRK2帕金森病的疾病.神经退行症的神经退行症多基因风险得分的多基因风险得分.

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