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理性设计的InhA抑制剂:对异化的硫酸盐和其结构灵活的基类同类物的抗结核活性进行比较研究

Mukanda Gedeon Kadima1, Sahil Mishra2, Gobind Kumar2

  • 1Discipline of Pharmaceutical Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.

Chemical biology & drug design
|September 10, 2025
PubMed
概括

研究人员通过将异化与芳香结构结合起来,开发出新的混合分子来对抗结核病. 最强效的化合物对Mycobacterium tuberculosis表现出强烈的活性,但对抗性菌株缺乏有效性,这表明新抗结核药物的有希望的支架.

关键词:
结核病菌菌菌的结核病菌的结核病菌.ADME/TT 在这里.灵活性 灵活性 灵活性氨酸是什么 氨酸是什么异化是一种异化.分子对接的分子对接.分子混合物分子混合物刚性 刚性 刚性 刚性

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