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杜普伊特伦病的手术和注射干预:系统审查协议

Rodrigo Guerra Sabongi¹, Vinicius Ynoe de Moraes¹, João Baptista Gomes Dos Santos¹

¹Disciplina de Cirurgia da Mão e Membro Superior, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Revista brasileira de ortopedia

|September 10, 2025

概括

本系统性综述比较了杜普伊特伦病 (Dupuytren's disease,DD) 的手术和注射治疗方法. 它旨在根据有效性和安全性使用网络元分析对干预措施进行排名,以指导临床决策.

科学领域:

整形外科和手术手术
基于证据的医学基于证据的医学.
药理学药理学是指药理学的学科.

背景情况:

杜普伊特伦病 (Dupuytren's disease,DD) 是一种影响手部的渐进性纤维状疾病.
目前DD的治疗选择包括手术和注射干预.
缺乏对这些干预措施的全面比较.

研究的目的:

对杜普伊特伦病的手术和注射干预措施的有效性和安全性进行系统审查和网络元分析.
为所有符合条件的干预措施生成比较估计,包括直接和间接证据.
根据疗效和安全性概况对治疗方法进行排名.

主要方法:

遵守PRISMA-P指南和PROSPERO注册的协议.
包括成年DD患者的随机对照试验 (RCT).
在多个数据库和试验注册表中进行全面的文献搜索,不受限制.
由两个审稿人进行的独立数据提取和偏差风险评估 (RoB2).
通过随机效应对联和网络元分析进行合成,以GRADE为证据确定性.
分析子组以探索异质性.

主要成果:

使用患者报告的结果指标 (PROMs) 合成的功能性结果.
对所有干预措施产生的有效性和安全性的比较估计.
基于合成的疗效和安全数据对治疗方法的排名.

结论:

本系统性审查解决了杜普伊特伦病治疗中的证据缺口.
为明智的临床决策提供功能和安全结果的强大综合.
旨在指导临床医生选择最有效和最安全的DD干预措施.

关键词:

杜普伊特伦合同的合同原酶是一种原酶.这是一种fasciotomy."系统审查"是指系统的审查.

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