在基于人口的队列中对单微生物肠球菌血流感染进行了为期5年的流行病学研究
David R Bayless1, Larry M Baddour2,3, Brian D Lahr4
1Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Open forum infectious diseases
|September 10, 2025
概括
单微生物肠球菌血流感染 (ME-BSI) 在老年男性中更为常见,死亡率高. 几乎七分之一的病例会发展成传染性内心炎,这凸显了对这种严重感染的进一步研究的需要.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 临床微生物学 临床微生物学
背景情况:
- 肠球菌血流感染 (BSI) 在美国缺乏基于人口的发病率和流行病学数据.
- 之前的研究还没有全面评估这些感染的大规模的临床特征.
研究的目的:
- 确定单微生物肠球菌血流感染 (ME-BSI) 的发病率,流行病学和临床特征.
- 在一个定义的人群中调查与ME-BSI相关的风险因素和结果.
主要方法:
- 使用扩展罗切斯特流行病学项目进行了一项基于人口的回顾性研究.
- 从2018年1月1日到2022年12月31日期间,明尼苏达州8个县的成年居民收集了数据.
- 确定并分析了单微生物肠球菌BSI病例的发病率,来源,病原体和死亡率.
主要成果:
- 经年龄和性别调整后,ME-BSI的发病率为每10万人/年6.7.
- 男性性别和年龄较大独立地与ME-BSI发病率的增加有关.
- 尿路感染是最常见的来源 (42.2%),Enterococcus faecalis是主要的病原体 (83.5%),1年死亡率为43.1%.
结论:
- 在美国人口中,ME-BSI与年龄较大和男性性别有显著的关联.
- 在ME-BSI病例中,很大一部分 (14.4%) 患有确定的传染性内心炎.
- 高死亡率和并发症率强调了ME-BSI的临床意义.
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