斯乔格伦综合征和动脉样硬化之间的因果关系:双向,双样本,孟德尔随机化研究
Luoyang Jing1, Zhaolong Liu1, Haolin Li1
1School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, CHN.
Cureus
|September 10, 2025
概括
肖格伦综合征 (SS) 可能会增加冠状动脉,大脑和外周动脉样硬化 (AS) 的风险. 外围的AS似乎也对SS的发展做出了贡献,这表明了双向关系.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
背景情况:
- 斯乔格伦综合征 (SS) 和动脉样硬化 (AS) 具有共同的炎症途径.
- 观察性研究表明,SS与AS风险增加之间存在联系,但因果关系尚不清楚.
- 这项研究使用孟德尔随机化研究SS和冠状动脉,大脑和外围AS之间的双向因果关系.
研究的目的:
- 为了确定SS是否因果关系影响不同类型AS的发展风险.
- 调查AS是否因果关系影响发展SS的风险.
- 探索SS和AS亚型之间的双向遗传关系.
主要方法:
- 利用孟德尔的随机化 (MR) 与来自大型全基因组关联研究 (GWAS) 的遗传变异.
- 采用反变量加权 (IVW) 作为主要方法,并补充加权中位数,MR-Egger和基于模式的方法.
- 通过使用科克兰的Q,MR-Egger拦截,MR-PRESSO和留出一项分析来评估状性和结果稳定性.
主要成果:
- 斯斯显示出对冠状动脉 (OR=1.046),大脑 (OR=1.320) 和外围AS (OR=1.154) 的风险增加的遗传倾向.
- 反向MR分析表明,外围AS因果上增加了SS风险 (OR=1.751).
- 对于冠状动脉或大脑AS在SS上没有发现显著的反向因果作用.
结论:
- 提出了SS和外围AS之间的双向因果关系的遗传证据.
- 表明SS对冠状动脉和大脑AS的单向因果作用.
- 强调需要对SS患者进行心血管查和综合管理,因为SS患者患有免疫血管并发症.
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