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Nadia Artha Dewi¹, Muhammad Arfan¹, Herisa Rahmasari¹

¹Ophthalmology Department, Medical Faculty, Universitas Brawijaya, Malang, Indonesia.

Clinical ophthalmology (Auckland, N.Z.)

|September 10, 2025

概括

黄斑血管密度在2型糖尿病患者中减少,即使没有视网膜病变,随着年龄的增长而下降. 其他临床因素,如HbA1c没有显示相关性.

科学领域:

眼科医生眼科眼科
糖尿病学糖尿病学
医疗成像医学成像

背景情况:

2型糖尿病 (DM) 是一种全身性疾病,具有潜在的眼部并发症.
早期检测视网膜中的微血管变化对于管理糖尿病眼病至关重要.
光学连贯断层扫描血管造影 (OCTA) 允许对黄斑血管系统进行非侵入性评估.

研究的目的:

为了评估2型DM但没有视网膜病变的患者的斑点血管密度.
评估斑点血管密度与临床参数 (如年龄,HbA1c,疾病持续时间和对比度敏感度) 之间的相关性.

主要方法:

一项横截面研究包括32名患有2型糖尿病的参与者 (32只眼睛) 和对照组.
使用OCTA (6x6毫米扫描) 测量了斑点血管密度.
用斯皮尔曼的等级相关性和独立的t测试来分析数据.

主要成果:

与健康对照组相比,DM组的中央黄斑血管密度明显较低 (p=0.002).
整个黄斑血管密度在DM组中也较低,但不显著 (p=0.070).
在DM患者中,斑点血管密度与年龄负相关 (中心:r=-0.522,p=0.002;整体:r=-0.369,p=0.038).
在斑点血管密度和HbA1c,疾病持续时间或对比度敏感性之间没有发现显著的相关性.

结论:

与健康个体相比,没有视网膜病变的2型糖尿病患者的斑点血管密度减少.
在2型糖尿病患者中,随着年龄的增长,斑点血管密度下降.
临床参数如HbA1c,疾病持续时间和对比度灵敏度在这个队列中没有与黄斑血管密度相关.

关键词:

2型糖尿病是第二类糖尿病.足骨的密度足骨的密度光学连贯性断层扫描血管图谱帕拉福维亚尔密度 (parafoveal density) 是一个比较大的密度.

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