在实验室中意外产生气溶和与实验室相关的感染的审查
Ashley R Ravnholdt1, Shanna A Ratnesar-Shumate1,2, Joshua L Santarpia1,2,3
1Global Center for Health Security, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Applied biosafety : journal of the American Biological Safety Association
|September 10, 2025
概括
从传染性气溶中获得的实验室感染 (LAI) 仍然是一个风险. 本次审查强调了气溶动态和报告方面的知识差距,敦促加强生物安全协议,以防止吸入暴露.
科学领域:
- 微生物学 微生物学
- 职业健康 职业健康 职业健康
- 生物安全 生物安全
背景情况:
- 尽管采取了先进的生物安全措施,但实验室获得的感染 (LAI) 仍然存在.
- 吸入传染性气溶是 LAI 的重要途径.
研究的目的:
- 审查在实验室中意外产生气溶的研究.
- 检查来自气溶暴露的LAI事件,并确定知识差距.
主要方法:
- 使用PubMed和谷歌学者进行了一项文献审查.
- 确定和合成了38篇涉及传染性气溶的LAI文章.
主要成果:
- 在了解气溶动力学 (例如粒子大小) 方面存在重大差距.
- 目前的LAI报告实践是不充分的.
- 实验室自动化对气溶产生的影响需要进一步研究.
结论:
- 为了减轻气溶风险,全面的安全协议至关重要.
- 为了更好的生物安全,需要改进文档和标准化报告.
- 进一步研究气溶动力学及其在 LAI 中的作用至关重要.
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