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基于突变的新辅助治疗,用于晚期形甲状腺癌

Sabine Wächter¹, Detlef K Bartsch¹, J Riera Knorrenschild²

¹Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.

Frontiers in endocrinology

|September 10, 2025

概括

结合向药物和免疫检查点抑制剂的新辅助疗法对晚期厌塑性甲状腺癌 (ATC) 是有前途的,可能使瘤可切除. 需要进一步的研究来确认其在多式联络治疗策略中的作用.

科学领域:

在瘤学瘤学.
甲状腺癌研究研究
翻译医学是一种翻译医学.

背景情况:

无塑性甲状腺癌 (ATC) 的预后不佳,需要新的治疗策略.
基于突变的向疗法和免疫检查点抑制剂 (ICI) 是先进的ATC的新兴选择.

研究的目的:

评估基于突变的新辅助疗法在将不可切除的ATC转化为可切除的状态中的疗效.
为了优化局部瘤控制和改善高级ATC患者的整体存活率.

主要方法:

晚期ATC患者接受了lenvatinib加pembrolizumab (BRAFV600E阴性) 或dabrafenib加trametinib (BRAFV600E阳性) 在4-6周内.
使用FDG-PET/CT重新分期评估了瘤反应;如果观察到回归,则进行了手术切除.
辅助基因突变系统治疗在手术后继续进行.

主要成果:

12名患者接受治疗;8名患者在新辅助疗法后显示瘤回归.
在9名患者中进行了手术切除,在8名患者中实现了R0/R1切除.
中位数无进展生存期为3个月,中位数整体生存期为9个月.

结论:

新辅助疗法是高级ATC患者的一个子集的有前途的方法.
最初的结果要求进一步调查其在多式联运空中管制管理中的作用.

关键词:

甲状腺癌的形性甲状腺癌.免疫检查点抑制剂免疫检查点抑制剂激酶抑制剂激酶抑制剂作为一种新辅助治疗,新辅助治疗.有针对性的治疗方法.

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