相关实验视频

Updated: May 7, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

在复合EGFR-突变的低甲基缩性肺肉类癌中,对基于免疫治疗的异常反应:一个病例报告

Ayushi Gianchandani¹, Darshana Desai², Janani Sambath^3,4

¹Imperial College London, London, United Kingdom.

Journal of immunotherapy and precision oncology

|September 10, 2025

概括

本案例研究显示,一种罕见的肺肉类瘤 (PSC) 具有复合EGFR突变,在TKI耐药后对免疫治疗有反应. 它表明,在特定情况下,免疫疗法可能有利于EGFR突变NSCLC.

科学领域:

在瘤学瘤学.
肺部病理学肺部病理学
遗传学是一个遗传学.

背景情况:

肺肉类瘤 (PSC) 是一种罕见的,侵袭性的非小细胞肺癌 (NSCLC).
在NSCLC中EGFR突变通常预测对氨酸激酶抑制剂 (TKI) 的反应,但对免疫治疗的抵抗性.
复合EGFR突变的PSC带来了独特的治疗挑战.

研究的目的:

报告一种带有复合EGFR突变的寡头转移性PSC病例.
为了研究免疫疗法的有效性,一个TKI耐药,EGFR突变的PSC.
突出在罕见的肺癌中个性化治疗策略的潜力.

主要方法:

一个患有含有复合EGFR突变 (p.G719C和S768I) 的寡头转移性PSC患者的病例报告.
连续治疗的审查,包括EGFRTKIs (osimertinib,afatinib,mobocertinib) 和化疗.
免疫疗法 (pembrolizumab) 与化疗 (卡博普拉丁,帕克利塔克塞尔) 的使用,然后进行双边上腺切除术.

主要成果:

患者在连续的EGFR TKI和化疗方案中表现出疾病进展.
在免疫疗法与化疗相结合时,观察到显著的反应.
在双边上腺切除术后,获得了完整的病理反应,随访时没有复发.

结论:

这个案子质疑了EGFR突变NSCLC对免疫疗法的耐药性.
免疫疗法可能为具有特定EGFR突变的PSC等罕见亚型提供可行的治疗选择.
综合的分子分析和个性化治疗对于优化侵袭性肺癌的结果至关重要.

关键词:

在EGFR的突变中.免疫疗法免疫疗法肺部肉类瘤 (PSC) 肺部肉类瘤

更多相关视频

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.